Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Natural killer cells remember

Cells of the adaptive immune system hold a grudge: on re-encountering a pathogen, they show a robust protective response. It seems that natural killer cells of the innate immune system might also have this ability.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Natural killer cells and virus exposure.


  1. Gourley, T. S. et al. Semin. Immunol. 16, 323–333 (2004).

    Article  CAS  Google Scholar 

  2. Sun, J. C., Beilke, J. N. & Lanier, L. L. Nature 457, 557–561 (2009).

    Article  CAS  ADS  Google Scholar 

  3. Pancer, Z. & Cooper, M. D. Annu. Rev. Immunol. 24, 497–518 (2006).

    Article  CAS  Google Scholar 

  4. Vivier, E. et al. Nature Immunol. 9, 503–510 (2008).

    Article  CAS  Google Scholar 

  5. Smith, H. R. et al. Proc. Natl Acad. Sci. USA 99, 8826–8831 (2002).

    Article  CAS  ADS  Google Scholar 

  6. Arase, H. et al. Science 296, 1323–1326 (2002).

    Article  CAS  ADS  Google Scholar 

  7. Dokun, A. O. et al. Nature Immunol. 2, 951–956 (2001).

    Article  CAS  Google Scholar 

  8. Selin, L. K. et al. Immunol. Rev. 211, 164–181 (2006).

    Article  CAS  Google Scholar 

  9. Glas, R. et al. J. Exp. Med. 191, 129–138 (2000).

    Article  CAS  Google Scholar 

  10. Raulet, D. H. Nature Immunol. 5, 996–1002 (2004).

    Article  CAS  Google Scholar 

  11. Raulet, D. H. & Vance, R. E. Nature Rev. Immunol. 6, 520–531 (2006).

    Article  CAS  Google Scholar 

  12. Lucas, M. et al. Immunity 26, 503–517 (2007).

    Article  CAS  Google Scholar 

  13. Vivier, E. & Malissen, B. Nature Immunol. 6, 17–21 (2005).

    Article  CAS  Google Scholar 

  14. Zinkernagel, R. M. & Hengartner, H. Immunol. Rev. 211, 310–319 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ugolini, S., Vivier, E. Natural killer cells remember. Nature 457, 544–545 (2009).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing