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Synthetic biology

The yin and yang of nature

Oscillations in gene expression regulate various cellular processes and so must be robust and tunable. Interactions between both negative and positive feedback loops seem to ensure these features.

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  1. Tigges, M., Marquez-Lago, T. T., Stelling, J. & Fussenegger, M. Nature 457, 309–312 (2009).

    Article  ADS  CAS  Google Scholar 

  2. Stricker, J. et al. Nature 456, 516–519 (2008).

    Article  ADS  CAS  Google Scholar 

  3. Tsai, T. Y.-C. et al. Science 321, 126–129 (2008).

    Article  ADS  CAS  Google Scholar 

  4. Elowitz, M. B. & Leibler, S. Nature 403, 335–338 (2000).

    Article  ADS  CAS  Google Scholar 

  5. Hasty, J., Dolnik, M., Rottschäfer, V. & Collins, J. J. Phys. Rev. Lett. 88, 148101 (2002).

    Article  ADS  Google Scholar 

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Gore, J., van Oudenaarden, A. The yin and yang of nature. Nature 457, 271–272 (2009).

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