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Stem cells

Tailor-made diseased neurons

How can we investigate a disease affecting neurons, which cannot be isolated from patients for analysis? As the study of one neurological disorder shows, a first step might be to make patient-specific neurons.

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References

  1. Ebert, A. D. et al. Nature 457, 277–280 (2009).

    Article  ADS  CAS  Google Scholar 

  2. Schrank, B. et al. Proc. Natl Acad. Sci. USA 94, 9920–9925 (1997).

    Article  ADS  CAS  Google Scholar 

  3. Wang, J. & Dreyfuss, G. J. Biol. Chem. 276, 9599–9605 (2001).

    Article  CAS  Google Scholar 

  4. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    Article  CAS  Google Scholar 

  5. Hanna, J. et al. Science 318, 1920–1923 (2007).

    Article  ADS  CAS  Google Scholar 

  6. Dimos, J. T. et al. Science 321, 1218–1221 (2008).

    Article  ADS  CAS  Google Scholar 

  7. Lobsiger, C. S. & Cleveland, D. W. Nature Neurosci. 10, 1355–1360 (2007).

    Article  CAS  Google Scholar 

  8. Di Giorgio, F. P., Boulting, G. L., Bobrowicz, S. & Eggan, K. C. Cell Stem Cell 3, 637–648 (2008).

    Article  CAS  Google Scholar 

  9. Nishimune, H., Sanes, J. R. & Carlson, S. S. Nature 432, 580–587 (2004).

    Article  ADS  CAS  Google Scholar 

  10. Jablonka, S., Beck, M., Lechner, B. D., Mayer, C. & Sendtner, M. J. Cell Biol. 179, 139–149 (2007).

    Article  CAS  Google Scholar 

Download references

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Sendtner, M. Tailor-made diseased neurons. Nature 457, 269–270 (2009). https://doi.org/10.1038/457269a

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