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Barrier to electrical storms

Epilepsy is characterized by repetitive seizures due to abnormal electrical activity in the brain. Immune cells promote development of this disorder by mediating the breakdown of the blood–brain barrier.

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Figure 1: Role of the immune system in epilepsy.


  1. Janigro, D. Epilepsy Curr. 7, 105–107 (2007).

    Article  Google Scholar 

  2. Kim, J. V., Kang, S. S., Dustin, M. L. & McGavern, D. B. Nature 457, 191–195 (2009).

    ADS  CAS  Article  Google Scholar 

  3. Fabene, P. F. et al. Nature Med. 14, 1377–1383 (2008).

    CAS  Article  Google Scholar 

  4. Kivisakk, P. et al. Ann. Neurol. doi:10.1002/ana.21379 (2008).

  5. Ransohoff, R. M., Kivisakk, P. & Kidd, G. Nature Rev. Immunol. 3, 569–581 (2003).

    CAS  Article  Google Scholar 

  6. Marchi, N. et al. Epilepsia 48, 732–742 (2007).

    CAS  Article  Google Scholar 

  7. van Vliet, E. A. et al. Brain 130, 521–534 (2007).

    CAS  Article  Google Scholar 

  8. Ivens, S. et al. Brain 130, 535–547 (2007).

    Article  Google Scholar 

  9. Rigau, V. et al. Brain 130, 1942–1956 (2007).

    Article  Google Scholar 

  10. Ransohoff, R. M. N. Engl. J. Med. 356, 2622–2629 (2007).

    CAS  Article  Google Scholar 

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Ransohoff, R. Barrier to electrical storms. Nature 457, 155–156 (2009).

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