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Alzheimer's disease

A prion protein connection

More than 20 million people worldwide have Alzheimer's disease, yet its causes remain mostly uncertain. Fresh findings provide molecular clues, linking this disease to another neurodegenerative disorder.

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Figure 1: PrP and Aβ-induced synaptic toxicity.

References

  1. 1

    Lesné, S. et al. Nature 440, 352–357 (2006).

    ADS  Article  Google Scholar 

  2. 2

    Cheng, I. H. et al. J. Biol. Chem. 282, 23818–23828 (2007).

    CAS  Article  Google Scholar 

  3. 3

    Shankar, G. M. et al. J. Neurosci. 27, 2866–2875 (2007).

    CAS  Article  Google Scholar 

  4. 4

    Laurén, J., Gimbel, D. A., Nygaard, H. B., Gilbert, J. W. & Strittmatter, S. M. Nature 457, 1128–1132 (2009).

    ADS  Article  Google Scholar 

  5. 5

    Aguzzi, A., Baumann, F. & Bremer, J. Annu. Rev. Neurosci. 31, 439–477 (2008).

    CAS  Article  Google Scholar 

  6. 6

    Prusiner, S. B. Annu. Rev. Med. 38, 381–398 (1987).

    CAS  Article  Google Scholar 

  7. 7

    Verdier, Y., Zarándi, M. & Penke, B. J. Pept. Sci. 10, 229–248 (2004).

    CAS  Article  Google Scholar 

  8. 8

    Sturchler, E., Galichet, A., Weibel, M., Leclerc, E. & Heizmann, C. W. J. Neurosci. 28, 5149–5158 (2008).

    CAS  Article  Google Scholar 

  9. 9

    Origlia, N. et al. J. Neurosci. 28, 3521–3530 (2008).

    CAS  Article  Google Scholar 

  10. 10

    Vincent, B., Cisse, M. A., Sunyach, C., Guillot-Sestier, M.-V. & Checler, F. Curr. Alzheimer Res. 5, 202–211 (2008).

    CAS  Article  Google Scholar 

  11. 11

    Shankar, G. M. et al. Nature Med. 14, 837–842 (2008).

    CAS  Article  Google Scholar 

  12. 12

    Roberson, E. D. et al. Science 316, 750–754 (2007).

    ADS  CAS  Article  Google Scholar 

  13. 13

    Wang, X.-F. et al. Mol. Cell. Biochem. 310, 49–55 (2008).

    CAS  Article  Google Scholar 

  14. 14

    Mouillet-Richard, S. et al. Science 289, 1925–1928 (2000).

    ADS  CAS  Article  Google Scholar 

  15. 15

    Chin, J. et al. J. Neurosci. 25, 9694–9703 (2005).

    CAS  Article  Google Scholar 

Download references

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Cisse, M., Mucke, L. A prion protein connection. Nature 457, 1090–1091 (2009). https://doi.org/10.1038/4571090a

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