An analysis of neuronal proteins reveals that many are regulated through covalent attachment of the lipid palmitate. This reversible modification seems to affect the form and function of synaptic junctions.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Kang, R. et al. Nature 456, 904–909 (2008).
Roth, A. F. et al. Cell 125, 1003–1013 (2006).
Drisdel, R. C. & Green, W. N. Biotechniques 36, 276–285 (2004).
Ethell, I. M. & Pasquale, E. B. Prog. Neurobiol. 75, 161–205 (2005).
Marks, P. W. & Kwiatkowski, D. J. Genomics 38, 13–18 (1996).
Hering, H., Lin, C. C. & Sheng, M. J. Neurosci. 23, 3262–3271 (2003).
Smotrys, J. E. & Linder, M. E. Annu. Rev. Biochem. 73, 559–587 (2004).
Halpain, S., Hipolito, A. & Saffer, L. J. Neurosci. 18, 9835–9844 (1998).
Tsutsumi, R., Fukata, Y. & Fukata, M. Pflügers Arch. 456, 1199–1206 (2008).
About this article
Cite this article
Linder, M. Greasy proteins of the neuron. Nature 456, 887–888 (2008). https://doi.org/10.1038/456887a