Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Greasy proteins of the neuron

An analysis of neuronal proteins reveals that many are regulated through covalent attachment of the lipid palmitate. This reversible modification seems to affect the form and function of synaptic junctions.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout


  1. Kang, R. et al. Nature 456, 904–909 (2008).

    Article  ADS  CAS  Google Scholar 

  2. Roth, A. F. et al. Cell 125, 1003–1013 (2006).

    Article  CAS  Google Scholar 

  3. Drisdel, R. C. & Green, W. N. Biotechniques 36, 276–285 (2004).

    Article  CAS  Google Scholar 

  4. Ethell, I. M. & Pasquale, E. B. Prog. Neurobiol. 75, 161–205 (2005).

    Article  CAS  Google Scholar 

  5. Marks, P. W. & Kwiatkowski, D. J. Genomics 38, 13–18 (1996).

    Article  CAS  Google Scholar 

  6. Hering, H., Lin, C. C. & Sheng, M. J. Neurosci. 23, 3262–3271 (2003).

    Article  CAS  Google Scholar 

  7. Smotrys, J. E. & Linder, M. E. Annu. Rev. Biochem. 73, 559–587 (2004).

    Article  CAS  Google Scholar 

  8. Halpain, S., Hipolito, A. & Saffer, L. J. Neurosci. 18, 9835–9844 (1998).

    Article  CAS  Google Scholar 

  9. Tsutsumi, R., Fukata, Y. & Fukata, M. Pflügers Arch. 456, 1199–1206 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Linder, M. Greasy proteins of the neuron. Nature 456, 887–888 (2008).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing