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Circadian clocks

Tips from the tip of the iceberg

Daily remodelling of histone proteins underlies interactions between circadian clock genes and metabolic genes. This regulatory mechanism could be widespread, affecting other physiological processes.

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Figure 1: Clock genes in health and disease.


  1. Alenghat, T. et al. Nature 456, 997–1000 (2008).

    Article  ADS  CAS  Google Scholar 

  2. Takahashi, J., Turek, F. & Moore, R. (eds) Handbook of Behavioural Neurobiology Vol. 12 (Kluwer Academic/Plenum, 2001).

    Book  Google Scholar 

  3. Panda, S. et al. Cell 109, 307–320 (2002).

    Article  CAS  Google Scholar 

  4. Turek, F. et al. Science 308, 1043–1045 (2005).

    Article  ADS  CAS  Google Scholar 

  5. Preitner, N. et al. Cell 110, 251–260 (2002).

    Article  CAS  Google Scholar 

  6. Ripperger, J. & Schibler, U. Nature Genet. 38, 369–374 (2006).

    Article  CAS  Google Scholar 

  7. Doi, M., Hirayama, J. & Sassone-Corsi, P. Cell 125, 497–508 (2006).

    Article  CAS  Google Scholar 

  8. Etchegaray, J. et al. Nature 421, 177–182 (2003).

    Article  ADS  CAS  Google Scholar 

  9. Ramsey, K. et al. Annu. Rev. Nutr. 27, 219–240 (2007).

    Article  CAS  Google Scholar 

  10. Naylor, E. et al. J. Neurosci. 20, 8138–8143 (2000).

    Article  CAS  Google Scholar 

  11. McClung, C. A. Pharmacol. Ther. 114, 222–232 (2007).

    Article  CAS  Google Scholar 

  12. Renthal, W. & Nestler, E. J. Trends Mol. Med. 14, 341–350 (2008).

    Article  CAS  Google Scholar 

  13. Sharma, R. Schizophr. Res. 72, 79–90 (2005).

    Article  Google Scholar 

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Competing interests

The author has been a consultant and has received an honorarium and/or grant support from the following companies with an interest in sleep/circadian rhythms: Merck; Astra-Zeneca; Servier; Sanofi-Aventis, Resporonics; and Johnson & Johnson. He is also chief executive of (and holds equity in) a small company, NuNetix Inc., that works with pharmaceutical companies to test their compounds for effects on sleep and/or circadian rhythms.

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Turek, F. Tips from the tip of the iceberg. Nature 456, 881–883 (2008).

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