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Circadian clocks

Tips from the tip of the iceberg

Daily remodelling of histone proteins underlies interactions between circadian clock genes and metabolic genes. This regulatory mechanism could be widespread, affecting other physiological processes.

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Figure 1: Clock genes in health and disease.


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Competing interests

The author has been a consultant and has received an honorarium and/or grant support from the following companies with an interest in sleep/circadian rhythms: Merck; Astra-Zeneca; Servier; Sanofi-Aventis, Resporonics; and Johnson & Johnson. He is also chief executive of (and holds equity in) a small company, NuNetix Inc., that works with pharmaceutical companies to test their compounds for effects on sleep and/or circadian rhythms.

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Turek, F. Tips from the tip of the iceberg. Nature 456, 881–883 (2008).

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