Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Molecular biology

Spliceosome meets telomerase

The spliceosome is best known for shepherding primary messenger RNA transcripts to maturity. This enzyme complex also contributes to the synthesis of an enzyme that maintains chromosome ends.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Processing of telomerase RNA by the spliceosome.

References

  1. http://www.gateworld.net/atlantis/s4/transcripts/419.shtml

  2. Blasco, M. A. Nature Chem. Biol. 3, 640–648 (2007).

    CAS  Article  Google Scholar 

  3. Box, J. A., Bunch, J. T., Tang, W. & Baumann, P. Nature 456, 910–914 (2008).

    ADS  CAS  Article  Google Scholar 

  4. Blackburn, E. H. FEBS Lett. 579, 859–862 (2005).

    CAS  Article  Google Scholar 

  5. Leonardi, J., Box, J. A., Bunch, J. T. & Baumann, P. Nature Struct. Mol. Biol. 15, 26–33 (2008).

    CAS  Article  Google Scholar 

  6. Webb, C. J. & Zakian, V. A. Nature Struct. Mol. Biol. 15, 34–42 (2008).

    CAS  Article  Google Scholar 

  7. Will, C. L. & Lührmann, R. in The RNA World 3rd edn (eds Gesteland, R. F., Cech, T. R. & Atkins, J. F.) 369–400 (Cold Spring Harbor Laboratory Press, 2005).

    Google Scholar 

  8. Tomás-Loba, A. et al. Cell 135, 609–622 (2008).

    Article  Google Scholar 

  9. Chapon, C., Cech, T. R. & Zaug, A. J. RNA 3, 1337–1351 (1997).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Fu, D. & Collins, K. Mol. Cell 11, 1361–1372 (2003).

    CAS  Article  Google Scholar 

  11. Mattick, J. S. & Makunin, I. V. Hum. Mol. Genet. 15, R17–R29 (2006).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bonnal, S., Valcárcel, J. Spliceosome meets telomerase. Nature 456, 879–880 (2008). https://doi.org/10.1038/456879a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/456879a

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing