Figure 1 : Molecular basis of long-term potentiation (LTP).

From: Along memory lane

Figure 1

Neurons receive synaptic transmission from other neurons (not shown) at dendritic spines. Strengthening of synapses during LTP — a cellular correlate of memory — requires the delivery of receptors and membrane pieces to spines by a myosin V motor protein1,7. Influx of Ca2+ through NMDA receptors activates myosin V in spines. The active motor protein then moves to the dendrite shaft and binds to Rab11/Rab11-FIP2 on recycling endosomes containing AMPA receptors. Finally, it transports the cargo into and along spines via actin filaments to mediate insertion of AMPA receptors at the cell surface, as well as spine growth through membrane insertion.