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Molecular biology

The Bloom's complex mousetrap

Genomic instability often underlies cancer. Analyses of proteins implicated in a cancer-predisposing condition called Bloom's syndrome illustrate the intricacies of protein interactions that ensure genomic stability.

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Figure 1: Double Holliday junctions caught in the mousetrap.


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Brosh, R. The Bloom's complex mousetrap. Nature 456, 453–454 (2008).

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