Genomic instability often underlies cancer. Analyses of proteins implicated in a cancer-predisposing condition called Bloom's syndrome illustrate the intricacies of protein interactions that ensure genomic stability.
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Ellis, N. A. et al. Cell 83, 655–666 (1995).
Hanada, K. & Hickson, I. D. Cell. Mol. Life Sci. 64, 2306–2322 (2007).
Xu, D. et al. Genes Dev. 22, 2843–2855 (2008).
Singh, T. R. et al. Genes Dev. 22, 2856–2868 (2008).
Wang, W. Nature Rev. Genet. 8, 735–748 (2007).
Hirano, S. et al. EMBO J. 24, 418–427 (2005).
Pichierri, P., Franchitto, A. & Rosselli, F. EMBO J. 23, 3154–3163 (2004).
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Brosh, R. The Bloom's complex mousetrap. Nature 456, 453–454 (2008). https://doi.org/10.1038/456453a