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Structural biology

Enzyme knocked for a loop

Protein-digesting enzymes are kept on a tight leash to stop them from wantonly attacking targets. Two crystal structures show how an inhibitory protein domain gags one such enzyme without being chewed up itself.

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Figure 1: It's a wrap for calpain.

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Mellgren, R. Enzyme knocked for a loop. Nature 456, 337–338 (2008). https://doi.org/10.1038/456337a

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