Protein-digesting enzymes are kept on a tight leash to stop them from wantonly attacking targets. Two crystal structures show how an inhibitory protein domain gags one such enzyme without being chewed up itself.
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References
Borth, W. FASEB J. 6, 3345–3353 (1992).
Estrada, S., Olson, S. T., Raub-Segall, E. & Bjork, I. Protein Sci. 9, 2218–2224 (2000).
Hanna, R. A., Campbell, R. L. & Davies, P. L. Nature 456, 409–412 (2008).
Moldoveanu, T., Gehring, K. & Green, D. R. Nature 456, 404–408 (2008).
Goll, D. E., Thompson, V. F., Li, H., Wei, W. & Cong, J. Physiol. Rev. 83, 731–801 (2003).
Dutt, P. et al. BMC Dev. Biol. 6, doi:10.1186/1471-213x/6/3 (2006).
Franco, S. J. & Huttenlocher, A. J. Cell Sci. 118, 3829–3838 (2005).
Kiss, R. et al. FEBS Lett. 582, 2149–2154 (2008).
Hosfield, C. M., Elce, J. S., Davies, P. L. & Jia, Z. EMBO J. 18, 6880–6889 (1999).
Moldoveanu, T. et al. Cell 108, 649–660 (2002).
Jia, Z. et al. Biophys. J. 80, 2590–2596 (2001).
Mellgren, R. L., Mericle, M. T. & Lane, R. D. Arch. Biochem. Biophys. 246, 233–239 (1986).
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Mellgren, R. Enzyme knocked for a loop. Nature 456, 337–338 (2008). https://doi.org/10.1038/456337a
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DOI: https://doi.org/10.1038/456337a
