Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cell biology

Nuclear order out of chaos

How cells build their internal structures remains one of the central mysteries in cell biology. If the cell nucleus is anything to go by, stochastic assembly and self-organization seem to be key.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Formation of nuclear structures.


  1. Kaiser, T. E., Intine, R. V. & Dundr, M. Science 10.1126/science.1165216 (2008).

  2. Misteli, T. Cell 128, 787–800 (2007).

    CAS  Article  PubMed  Google Scholar 

  3. Handwerger, K. E. & Gall, J. Trends Cell Biol. 16, 19–26 (2006).

    CAS  Article  PubMed  Google Scholar 

  4. Misteli, T. J. Cell Biol. 155, 181–185 (2001).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  5. Hebert, M. D. & Matera, A. G. Mol. Biol. Cell 11, 4159–4171 (2000).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  6. Shopland, L. S. et al. Mol. Biol. Cell 12, 565–576 (2001).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  7. Dundr, M. et al. J. Cell Biol. 179, 1095–1103 (2007).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Misteli, T. Nuclear order out of chaos. Nature 456, 333–334 (2008).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing