Small-scale interactions of substrates with an enzyme's active site — over distances smaller than the length of a chemical bond — can make big differences to the enzyme's catalytic efficiency.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Sigala, P. A. et al. J. Am. Chem. Soc. 130, 13696–13708 (2008).
Pauling, L. Chem. Eng. News 24, 1375–1377 (1946).
Wolfenden, R. Biophys. Chem. 105, 559–572 (2003).
Mader, M. M. & Bartlett, P. A. Chem. Rev. 97, 1281–1302 (1997).
Hilvert, D. Annu. Rev. Biochem. 69, 751–793 (2000).
Hollfelder, F., Kirby, A. J. & Tawfik, D. S. Nature 383, 60–63 (1996).
Kraut, D. A. et al. PLoS Biol. 4, e99 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kirby, A., Hollfelder, F. Enzymes under the nanoscope. Nature 456, 45–47 (2008). https://doi.org/10.1038/456045a
Published:
Issue Date:
DOI: https://doi.org/10.1038/456045a
