The childhood cancer neuroblastoma can either run in families or occur sporadically. Several studies find that the gene ALK is a chief offender in this disease, because its germline mutations mediate both forms.
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Eng, C. A ringleader identified. Nature 455, 883–884 (2008). https://doi.org/10.1038/455883a
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DOI: https://doi.org/10.1038/455883a
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