Prolonged physical interaction between helper T cells and antibody-producing B cells is crucial for efficient immune responses. Mutations in a protein that underlies this process cause human disease.
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References
Liu, Y. J. & Banchereau, J. Immunologist 4, 55–66 (1996).
MacLennan, I. C. M. Annu. Rev. Immunol. 12, 117–139 (1994).
Ma, C. S., Nichols, K. E. & Tangye, S. G. Annu. Rev. Immunol. 25, 337–379 (2007).
Qi, H., Cannons, J. L., Klauschen, F., Schwartzberg, P. L. & Germain, R. N. Nature 455, 764–769 (2008).
Vinuesa, C. G., Tangye, S. G., Moser, B. & Mackay, C. R. Nature Rev. Immunol. 5, 853–865 (2005).
Kim, C. H. et al. J. Exp. Med. 193, 1373–1381 (2001).
Haynes, N. M. et al. J. Immunol. 179, 5099–5108 (2007).
Ansel, K. M. et al. J. Exp. Med. 190, 1123–1134 (1999).
Graham, D. B. et al. J. Immunol. 176, 291–300 (2006).
McCausland, M. M. et al. J. Immunol. 178, 817–828 (2007).
Chtanova, T. et al. J. Immunol. 173, 68–78 (2004).
Chan, A. Y. et al. Curr. Opin. Immunol. 18, 656–664 (2006).
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Deenick, E., Tangye, S. Helpful T cells are sticky. Nature 455, 745–747 (2008). https://doi.org/10.1038/455745a
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DOI: https://doi.org/10.1038/455745a
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