Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Molecular biology

DNA endgames

If it is not repaired efficiently, damage to DNA double strands can have dire consequences for both the cell and the organism. Given the gravity of this situation, cells use two pathways to start the process.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Processing DNA's broken ends.


  1. Mimitou, E. P. & Symington, L. S. Nature 455, 770–774 (2008).

    Article  ADS  CAS  Google Scholar 

  2. Zhu, Z., Chung, W.-H., Shim, E. Y., Lee, S. E. & Ira, G. Cell 134, 981–994 (2008).

    Article  CAS  Google Scholar 

  3. Gravel, S., Chapman, J. R., Magill, C. & Jackson, S. P. Genes Dev. 22, 2767–2772 (2008).

    Article  CAS  Google Scholar 

  4. Sun, H., Treco, D. & Szostak, J. W. Cell 64, 1155–1161 (1991).

    Article  CAS  Google Scholar 

  5. White, C. I. & Haber, J. E. EMBO J. 9, 663–673 (1990).

    Article  CAS  Google Scholar 

  6. Furuse, M. et al. EMBO J. 17, 6412–6425 (1998).

    Article  CAS  Google Scholar 

  7. Llorente, B. & Symington, L. S. Mol. Cell. Biol. 24, 9682–9694 (2004).

    Article  CAS  Google Scholar 

  8. Paull, T. T. & Gellert, M. Mol. Cell 1, 969–979 (1998).

    Article  CAS  Google Scholar 

  9. Clerici, M., Mantiero, D., Lucchini, G. & Longhese, M. P. J. Biol. Chem. 280, 38631–38638 (2005).

    Article  CAS  Google Scholar 

  10. Lengsfeld, B. M. et al. Mol. Cell 28, 638–651 (2007).

    Article  CAS  Google Scholar 

  11. Amundsen, S. K. & Smith, G. R. Cell 112, 741–744 (2003).

    Article  CAS  Google Scholar 

  12. Myung, K., Datta, A., Chen, C. & Kolodner, R. D. Nature Genet. 27, 113–116 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Klein, H. DNA endgames. Nature 455, 740–741 (2008).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing