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Neuroscience

Fragile dopamine

Dopamine dysfunction, which is implicated in Parkinson's disease and drug addiction, seems an unlikely culprit in fragile X syndrome. A surprising set of findings means a rethink is required.

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Figure 1: FMRP-mediated regulation of dopamine signalling.

References

  1. Garber, K. B., Visootsak, J. & Warren, S. T. Eur. J. Hum. Genet. 16, 666–672 (2008).

    CAS  Article  Google Scholar 

  2. Penagarikano, O., Mulle, J. G. & Warren, S. T. Annu. Rev. Genomics Hum. Genet. 8, 109–129 (2007).

    CAS  Article  Google Scholar 

  3. Wang, H. et al. Neuron 59, 634–647 (2008).

    CAS  Article  Google Scholar 

  4. Wickens, J. R., Horvitz, J. C., Costa, R. M. & Killcross, S. J. Neurosci. 27, 8181–8183 (2007).

    CAS  Article  Google Scholar 

  5. Berridge, K. C. Psychopharmacology (Berl.) 191, 391–431 (2007).

    CAS  Article  Google Scholar 

  6. Calabresi, P., Picconi, B., Tozzi, A. & Di Filippo, M. Trends Neurosci. 30, 211–219 (2007).

    CAS  Article  Google Scholar 

  7. Brennan, A. R. & Arnsten, A. F. Ann. NY Acad. Sci. 1129, 236–245 (2008).

    ADS  Article  Google Scholar 

  8. Berry-Kravis, E. & Huttenlocher, P. R. Ann. Neurol. 31, 22–26 (1992).

    CAS  Article  Google Scholar 

  9. Kelley, D. J. et al. Neurosci. Biobehav. Rev. 32, 1533–1543 (2008).

    CAS  Article  Google Scholar 

  10. Hooper, S. R. et al. Neuropsychology 22, 36–47 (2008).

    Article  Google Scholar 

  11. Hatton, D. D. et al. Am. J. Med. Genet. A 108, 105–116 (2002).

    Article  Google Scholar 

  12. Bassell, G. J. & Gross, C. Nature Med. 14, 249–250 (2008).

    CAS  Article  Google Scholar 

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Weinshenker, D., Warren, S. Fragile dopamine. Nature 455, 607–608 (2008). https://doi.org/10.1038/455607a

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