The concentration of atmospheric carbon dioxide decreased between 45 million and 25 million years ago, a trend accompanied by glaciation at the poles. Modelling results suggest when and where the ice closed in.
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Pekar, S. When did the icehouse cometh?. Nature 455, 602–603 (2008). https://doi.org/10.1038/455602a
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DOI: https://doi.org/10.1038/455602a