When the myelin layer that covers neuronal processes is lost through disease, neural stem cells recapitulate the developmental program of 'myelination'. The underlying molecular mechanisms often fail in the ageing brain.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Temporal proteomic profiling of postnatal human cortical development
Translational Psychiatry Open Access 05 December 2018
-
Alzheimer’s associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia
Acta Neuropathologica Communications Open Access 24 September 2018
-
Msh2 deficiency leads to dysmyelination of the corpus callosum, impaired locomotion and altered sensory function in mice
Scientific Reports Open Access 01 August 2016
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Shen, S. et al. Nature Neurosci. 11, 1024–1034 (2008).
Trapp, B. D. & Nave, K.-A. Annu. Rev. Neurosci. 31, 247–269 (2008).
Blakemore, W. F. & Franklin, R. J. Curr. Top. Microbiol. Immunol. 318, 193–212 (2008).
Shen, S., Li, J. & Casaccia-Bonnefil, P. J. Cell Biol. 169, 577–589 (2005).
Charles, P. et al. Proc. Natl Acad. Sci. USA 97, 7585–7590 (2000).
Mi, S. et al. Nature Neurosci. 8, 745–751 (2005).
Back, S. A. et al. Nature Med. 11, 966–972 (2005).
Setzu, A. et al. Glia 54, 297–303 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nave, KA. An ageing view of myelin repair. Nature 455, 478–479 (2008). https://doi.org/10.1038/455478a
Published:
Issue Date:
DOI: https://doi.org/10.1038/455478a
This article is cited by
-
Alzheimer’s associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia
Acta Neuropathologica Communications (2018)
-
Temporal proteomic profiling of postnatal human cortical development
Translational Psychiatry (2018)
-
Msh2 deficiency leads to dysmyelination of the corpus callosum, impaired locomotion and altered sensory function in mice
Scientific Reports (2016)
-
Optimization of electron microscopy for human brains with long-term fixation and fixed-frozen sections
Acta Neuropathologica Communications (2014)
