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Systems biology

Metabonomics

Nature volume 455, pages 1054–1056 (2008)Cite this article

Organisms often respond in complex and unpredictable ways to stimuli that cause disease or injury. By measuring and mathematically modelling changes in the levels of products of metabolism found in biological fluids and tissues, metabonomics offers fresh insight into the effects of diet, drugs and disease.

What are the origins of the field?

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Figure 1: Metabonomics of yore.

THE ROYAL LIBRARY, COPENHAGEN

Figure 2: The discovery process in metabonomics.
Figure 3: Applications of metabonomics.

References

  1. Nicholson, J. K. & Wilson, I. D. Understanding 'global' systems biology: Metabonomics and the continuum of metabolism. Nature Rev. Drug Discov. 2, 668–676 (2003).

    CAS  Article  Google Scholar 

  2. Dethlefsen, L., McFall-Ngai, M. & Relman, D. A. An ecological and evolutionary perspective on human–microbe mutualism and disease. Nature 449, 811–818 (2007).

    ADS  CAS  Article  Google Scholar 

  3. Lenz, E. M. & Wilson, I. D. Analytical strategies in metabonomics. J. Proteome Res. 6, 443–458 (2007).

    CAS  Article  Google Scholar 

  4. Wishart, D. S. et al. HMDB: The Human Metabolome Database. Nucleic Acids Res. 35, D521–D526 (2007).

    CAS  Article  Google Scholar 

  5. Holmes, E., Wilson, I. D. & Nicholson, J. K. Metabolic phenotyping in health and disease. Cell 134, 714–717 (2008).

    CAS  Article  Google Scholar 

  6. Holmes, E. et al. Human metabolic phenotype diversity and its association with diet and blood pressure. Nature 453, 396–400 (2008).

    ADS  CAS  Article  Google Scholar 

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Authors and Affiliations

  1. Jeremy K. Nicholson and John C. Lindon are in the Department of Biomolecular Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK,

    Jeremy K. Nicholson & John C. Lindon

Authors
  1. Jeremy K. Nicholson
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  2. John C. Lindon
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Nicholson, J., Lindon, J. Metabonomics. Nature 455, 1054–1056 (2008). https://doi.org/10.1038/4551054a

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