Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Biochemistry

Cells enforce an ion curtain

Metal cofactors are an essential part of many proteins. But how is the right choice of metal made? For bacteria, one answer is to change the cellular compartment where cofactor insertion occurs.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Control of metal loading into bacterial periplasmic proteins.

References

  1. Holm, R. H., Kennepohl, P. & Solomon, E. I. Chem. Rev. 96, 2239–2314 (1996).

    CAS  Article  Google Scholar 

  2. Tottey, S. et al. Nature 455, 1138–1142 (2008).

    ADS  CAS  Article  Google Scholar 

  3. Irving, H. & Williams, R. J. P. Nature 162, 746–747 (1948).

    ADS  CAS  Article  Google Scholar 

  4. Fraústo da Silva, J. J. R. & Williams, R. J. P. The Biological Chemistry of the Elements 2nd edn (Oxford Univ. Press, 2001).

    Google Scholar 

  5. Berks, B. C., Palmer, T. & Sargent, F. Adv. Microb. Physiol. 47, 187–254 (2003).

    CAS  Article  Google Scholar 

  6. Ranquet, C., Ollagnier-de-Choudens, S., Loiseau, L., Barras, F. & Fontecave, M. J. Biol. Chem. 282, 30442–30451 (2007).

    CAS  Article  Google Scholar 

  7. Butt, J. N., Niles, J., Armstrong, F. A., Breton, J. & Thomson, A. J. Nature Struct. Biol. 1, 427–433 (1994).

    CAS  Article  Google Scholar 

  8. Zumft, W. G. & Kroneck, P. M. Adv. Microb. Physiol. 52, 107–227 (2007).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Berks, B. Cells enforce an ion curtain. Nature 455, 1043–1044 (2008). https://doi.org/10.1038/4551043a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/4551043a

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing