Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Small RNAs

The seeds of silence

Nature volume 455, pages 44–45 (2008)Cite this article

Individual microRNA sequences can suppress the production of hundreds of proteins. Reduction of protein levels in this way is often modest, however, and many such RNAs probably collectively fine-tune gene expression.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The techniques of SILAC and pulsed SILAC.

References

  1. Liu, X., Fortin, K. & Mourelatos, Z. Brain Pathol. 18, 113–121 (2008).

    Article  CAS  Google Scholar 

  2. Du, T. & Zamore, P. D. Development 132, 4645–4652 (2005).

    Article  CAS  Google Scholar 

  3. Selbach, M. et al. Nature 455, 58–63 (2008).

    Article  ADS  CAS  Google Scholar 

  4. Baek, D. et al. Nature 455, 64–71 (2008).

    Article  ADS  CAS  Google Scholar 

  5. Bartel, D. P. & Chen, C. Z. Nature Rev. Genet. 5, 396–400 (2004).

    Article  CAS  Google Scholar 

  6. Rajewsky, N. Nature Genet. 38 (Suppl.), S8–S13 (2006).

    Article  CAS  Google Scholar 

  7. Sethupathy, P., Megraw, M. & Hatzigeorgiou, A. G. Nature Methods 3, 881–886 (2006).

    Article  CAS  Google Scholar 

  8. Mann, M. Nature Rev. Mol. Cell Biol. 7, 952–958 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Zissimos Mourelatos is in the Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. mourelaz@uphs.upenn.edu,

    Zissimos Mourelatos

Authors
  1. Zissimos Mourelatos
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mourelatos, Z. The seeds of silence. Nature 455, 44–45 (2008). https://doi.org/10.1038/455044a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/455044a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing