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Immunology

Oxysterols hold T cells in check

The oxysterol-dependent gene transcription factor LXRβ restricts premature expansion of T cells by limiting cellular cholesterol levels. This pathway might be a pharmacological target for regulating immune responses.

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Figure 1: Response of T cells to a shift in cholesterol balance.

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Glass, C., Saijo, K. Oxysterols hold T cells in check. Nature 455, 40–41 (2008). https://doi.org/10.1038/455040a

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