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Systems biology

On the cell cycle and its switches

Nature volume 454, pages 288–289 (2008)Cite this article

For the cell-division cycle to progress, hundreds of genes and proteins must be coordinately regulated. Systems-level studies of this cycle show that positive-feedback loops help to keep events in sync.

The cell cycle is a complex but orderly sequence of events that culminates in the production of two cells from one. In eukaryotes, the cycle is divided into four phases: cell growth in G1 phase, DNA replication in S phase, more growth in G2 phase, and cell division in mitosis or M phase. The system of regulators that drives transitions between phases is centred on the cyclin-dependent kinases (CDKs), enzymes that are activated when regulatory proteins called cyclins bind to them. The CDK network directly or indirectly orchestrates coordinated regulation of proteins and genes involved in essentially every aspect of cell function. The complexity of these regulatory events raises the question of what systems-level strategies keep the process temporally coherent — how does the maestro of the cell cycle generate a definitive downbeat? Writing in this issue, Skotheim et al.1 and Holt et al.2 examine different phases of the cell cycle in the budding yeast Saccharomyces cerevisiae, and their findings converge on the same answer: positive feedback.

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Figure 1: Cell-cycle synchronizers.

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References

  1. Skotheim, J. M., Di Talia, S., Siggia, E. D. & Cross, F. R. Nature 454, 291–296 (2008).

    Article  ADS  CAS  Google Scholar 

  2. Holt, L. J., Krutchinsky, A. N. & Morgan, D. O. Nature 454, 353–357 (2008).

    Article  ADS  CAS  Google Scholar 

  3. Dirick, L., Böhm, T. & Nasmyth, K. EMBO J. 14, 4803–4813 (1995).

    Article  CAS  Google Scholar 

  4. Stuart, D. & Wittenberg, C. Genes Dev. 9, 2780–2794 (1995).

    Article  CAS  Google Scholar 

  5. Haase, S. B. & Reed, S. I. Nature 401, 394–397 (1999).

    ADS  CAS  PubMed  Google Scholar 

  6. Orlando, D. A. et al. Nature 453, 944–947 (2008).

    Article  ADS  CAS  Google Scholar 

  7. Tyson, J. J., Csikasz-Nagy, A. & Novak, B. BioEssays 24, 1095–1109 (2002).

    Article  CAS  Google Scholar 

  8. Cross, F. R., Archambault, V., Miller, M. & Klovstad, M. Mol. Biol. Cell 13, 52–70 (2002).

    Article  CAS  Google Scholar 

  9. Pomerening, J. R., Kim, S. Y. & Ferrell, J. E. Jr Cell 122, 565–578 (2005).

    Article  CAS  Google Scholar 

  10. Pomerening, J. R., Ubersax, J. A. & Ferrell, J. E. Jr Mol. Biol. Cell doi:10.1091/mbc.E08-02-0172 (2008). | Article |

  11. Cross, F. R. Dev. Cell 4, 741–752 (2003).

    Article  CAS  Google Scholar 

  12. Ferrell, J. E. Jr & Machleder, E. M. Science 280, 895–898 (1998).

    Article  ADS  CAS  Google Scholar 

  13. Gardner, T. S., Cantor, C. R. & Collins, J. J. Nature 403, 339–342 (2000).

    Article  ADS  CAS  Google Scholar 

  14. Xiong, W. & Ferrell, J. E. Jr Nature 426, 460–465 (2003).

    Article  ADS  CAS  Google Scholar 

  15. Thron, C. D. Biophys. Chem. 57, 239–251 (1996).

    Article  CAS  Google Scholar 

  16. Tsai, T. Y.-C. et al. Science 321, 126–129 (2008).

    Article  ADS  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Silvia D. M. Santos and James E. Ferrell are in the Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305–5174, USA. james.ferrell@stanford.edu,

    Silvia D. M. Santos & James E. Ferrell

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  1. Silvia D. M. Santos
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  2. James E. Ferrell
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Santos, S., Ferrell, J. On the cell cycle and its switches. Nature 454, 288–289 (2008). https://doi.org/10.1038/454288a

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