Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Systems biology

On the cell cycle and its switches

For the cell-division cycle to progress, hundreds of genes and proteins must be coordinately regulated. Systems-level studies of this cycle show that positive-feedback loops help to keep events in sync.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Cell-cycle synchronizers.

Similar content being viewed by others


  1. Skotheim, J. M., Di Talia, S., Siggia, E. D. & Cross, F. R. Nature 454, 291–296 (2008).

    Article  ADS  CAS  Google Scholar 

  2. Holt, L. J., Krutchinsky, A. N. & Morgan, D. O. Nature 454, 353–357 (2008).

    Article  ADS  CAS  Google Scholar 

  3. Dirick, L., Böhm, T. & Nasmyth, K. EMBO J. 14, 4803–4813 (1995).

    Article  CAS  Google Scholar 

  4. Stuart, D. & Wittenberg, C. Genes Dev. 9, 2780–2794 (1995).

    Article  CAS  Google Scholar 

  5. Haase, S. B. & Reed, S. I. Nature 401, 394–397 (1999).

    ADS  CAS  PubMed  Google Scholar 

  6. Orlando, D. A. et al. Nature 453, 944–947 (2008).

    Article  ADS  CAS  Google Scholar 

  7. Tyson, J. J., Csikasz-Nagy, A. & Novak, B. BioEssays 24, 1095–1109 (2002).

    Article  CAS  Google Scholar 

  8. Cross, F. R., Archambault, V., Miller, M. & Klovstad, M. Mol. Biol. Cell 13, 52–70 (2002).

    Article  CAS  Google Scholar 

  9. Pomerening, J. R., Kim, S. Y. & Ferrell, J. E. Jr Cell 122, 565–578 (2005).

    Article  CAS  Google Scholar 

  10. Pomerening, J. R., Ubersax, J. A. & Ferrell, J. E. Jr Mol. Biol. Cell doi:10.1091/mbc.E08-02-0172 (2008). | Article |

  11. Cross, F. R. Dev. Cell 4, 741–752 (2003).

    Article  CAS  Google Scholar 

  12. Ferrell, J. E. Jr & Machleder, E. M. Science 280, 895–898 (1998).

    Article  ADS  CAS  Google Scholar 

  13. Gardner, T. S., Cantor, C. R. & Collins, J. J. Nature 403, 339–342 (2000).

    Article  ADS  CAS  Google Scholar 

  14. Xiong, W. & Ferrell, J. E. Jr Nature 426, 460–465 (2003).

    Article  ADS  CAS  Google Scholar 

  15. Thron, C. D. Biophys. Chem. 57, 239–251 (1996).

    Article  CAS  Google Scholar 

  16. Tsai, T. Y.-C. et al. Science 321, 126–129 (2008).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Santos, S., Ferrell, J. On the cell cycle and its switches. Nature 454, 288–289 (2008).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing