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Systems biology

On the cell cycle and its switches

For the cell-division cycle to progress, hundreds of genes and proteins must be coordinately regulated. Systems-level studies of this cycle show that positive-feedback loops help to keep events in sync.

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Figure 1: Cell-cycle synchronizers.


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Santos, S., Ferrell, J. On the cell cycle and its switches. Nature 454, 288–289 (2008).

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