Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Systems biology

On the cell cycle and its switches

For the cell-division cycle to progress, hundreds of genes and proteins must be coordinately regulated. Systems-level studies of this cycle show that positive-feedback loops help to keep events in sync.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Cell-cycle synchronizers.

References

  1. Skotheim, J. M., Di Talia, S., Siggia, E. D. & Cross, F. R. Nature 454, 291–296 (2008).

    ADS  CAS  Article  Google Scholar 

  2. Holt, L. J., Krutchinsky, A. N. & Morgan, D. O. Nature 454, 353–357 (2008).

    ADS  CAS  Article  Google Scholar 

  3. Dirick, L., Böhm, T. & Nasmyth, K. EMBO J. 14, 4803–4813 (1995).

    CAS  Article  Google Scholar 

  4. Stuart, D. & Wittenberg, C. Genes Dev. 9, 2780–2794 (1995).

    CAS  Article  Google Scholar 

  5. Haase, S. B. & Reed, S. I. Nature 401, 394–397 (1999).

    ADS  CAS  PubMed  Google Scholar 

  6. Orlando, D. A. et al. Nature 453, 944–947 (2008).

    ADS  CAS  Article  Google Scholar 

  7. Tyson, J. J., Csikasz-Nagy, A. & Novak, B. BioEssays 24, 1095–1109 (2002).

    CAS  Article  Google Scholar 

  8. Cross, F. R., Archambault, V., Miller, M. & Klovstad, M. Mol. Biol. Cell 13, 52–70 (2002).

    CAS  Article  Google Scholar 

  9. Pomerening, J. R., Kim, S. Y. & Ferrell, J. E. Jr Cell 122, 565–578 (2005).

    CAS  Article  Google Scholar 

  10. Pomerening, J. R., Ubersax, J. A. & Ferrell, J. E. Jr Mol. Biol. Cell doi:10.1091/mbc.E08-02-0172 (2008). | Article |

  11. Cross, F. R. Dev. Cell 4, 741–752 (2003).

    CAS  Article  Google Scholar 

  12. Ferrell, J. E. Jr & Machleder, E. M. Science 280, 895–898 (1998).

    ADS  CAS  Article  Google Scholar 

  13. Gardner, T. S., Cantor, C. R. & Collins, J. J. Nature 403, 339–342 (2000).

    ADS  CAS  Article  Google Scholar 

  14. Xiong, W. & Ferrell, J. E. Jr Nature 426, 460–465 (2003).

    ADS  CAS  Article  Google Scholar 

  15. Thron, C. D. Biophys. Chem. 57, 239–251 (1996).

    CAS  Article  Google Scholar 

  16. Tsai, T. Y.-C. et al. Science 321, 126–129 (2008).

    ADS  CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Santos, S., Ferrell, J. On the cell cycle and its switches. Nature 454, 288–289 (2008). https://doi.org/10.1038/454288a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/454288a

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing