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Motor neuron disease

The curious ways of ALS

That mutations in the SOD1 enzyme underlie inherited forms of a motor neuron disease known as ALS is clear. But the question of what the consequences of such mutations are seems to have more than one answer.

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Figure 1: Proposed mechanisms of toxicity in SOD1-mediated ALS.


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Polymenidou, M., Cleveland, D. The curious ways of ALS. Nature 454, 284–285 (2008).

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