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Stem cells

Tips for priming potency

Introducing just four specific genes into adult cells causes them to regress to an embryonic stem-cell-like state. At 1%, the efficiency of this process is low, but two tips are at hand on how to make improvements.

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References

  1. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    CAS  Article  Google Scholar 

  2. Mikkelsen, T. S. et al. Nature 454, 49–55 (2008).

    ADS  CAS  Article  Google Scholar 

  3. Wilmut, I., Schnieke, A. E., McWhir, J., Kind, A. J. & Campbell, K. H. S. Nature 385, 810–813 (1997).

    ADS  CAS  Article  Google Scholar 

  4. Yamanaka, S. Phil. Trans. R. Soc. Lond. B 363, 2079–2087 (2008).

    CAS  Article  Google Scholar 

  5. Yu, J. et al. Science 318, 1917–1920 (2007).

    ADS  CAS  Article  Google Scholar 

  6. Park, I.-H. et al. Nature 451, 141–146 (2008).

    ADS  CAS  Article  Google Scholar 

  7. Takahashi, K. et al. Cell 131, 861–872 (2007).

    CAS  Article  Google Scholar 

  8. Aoi, T. et al. Science doi:10.1126/science.1154884 (2008).

  9. Bernstein, B. E. et al. Cell 125, 315–326 (2006).

    CAS  Article  Google Scholar 

  10. Maherali, N. et al. Cell Stem Cell 1, 55–70 (2007).

    CAS  Article  Google Scholar 

  11. Okita, K., Ichisaka, T. & Yamanaka, S. Nature 448, 313–317 (2007).

    ADS  CAS  Article  Google Scholar 

  12. Wernig, M. et al. Nature 448, 318–324 (2007).

    ADS  CAS  Article  Google Scholar 

  13. Nakagawa, M. et al. Nature Biotechnol. 26, 101–106 (2008).

    CAS  Article  Google Scholar 

  14. Hanna, J. et al. Science 318, 1920–1923 (2007).

    ADS  CAS  Article  Google Scholar 

  15. Hajkova, P. et al. Nature 452, 877–881 (2008).

    ADS  CAS  Article  Google Scholar 

Download references

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Costello, J. Tips for priming potency. Nature 454, 45–46 (2008). https://doi.org/10.1038/454045a

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  • DOI: https://doi.org/10.1038/454045a

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