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Structural biology

Modelling collagen diseases

Mutations in collagen lead to hereditary disorders such as brittle-bone disease. Peptide models for aberrant collagens are beginning to clarify how these amino-acid replacements lead to clinical problems.

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Figure 1: Collagen mutations mimicked by peptide models.


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Brodsky, B., Baum, J. Modelling collagen diseases. Nature 453, 998–999 (2008).

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