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Signal transduction

The rhodopsin story continued

Determination of the architecture of an invertebrate photoreceptor protein, squid rhodopsin, is a notable event. It illuminates the mechanism of invertebrate vision and a ubiquitous intracellular signalling system.

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Figure 1: The architecture of squid rhodopsin, as determined by Murakami and Kouyama2.


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Gebhard F. X. Schertler is a shareholder of, and scientific adviser to, Heptares Therapeutics, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, UK ( This company is involved in research on G-protein-coupled receptors and drug design.

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Schertler, G. The rhodopsin story continued. Nature 453, 292–293 (2008).

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