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Drug discovery

A lifeline for suffocating tissues

When a blood vessel becomes blocked, the ideal treatment would be a drug that induces new vessel formation in the damaged tissue, without affecting healthy tissues. With the chemical nitrite, we might be on to a winner.

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Figure 1: Targeted effect.


  1. 1

    Kumar, D. et al. Proc. Natl Acad. Sci. USA 105, 7540–7545 (2008).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Yla-Herttuala, S., Markkanen, J. E. & Rissanen, T. T. Trends Cardiovasc. Med. 14, 295–300 (2004).

    Article  PubMed  Google Scholar 

  3. 3

    Tirziu, D. & Simons, M. Angiogenesis 8, 241–251 (2005).

    Article  PubMed  Google Scholar 

  4. 4

    Luque Contreras, D., Vargas Robles, H., Romo, E., Rios, A. & Escalante, B. Pharmacol. Ther. 112, 553–563 (2006).

    CAS  Article  PubMed  Google Scholar 

  5. 5

    Moncada, S. & Higgs, A. N. Engl. J. Med. 329, 2002–2012 (1993).

    CAS  Article  PubMed  Google Scholar 

  6. 6

    Shiva, S. et al. J. Exp. Med. 204, 2089–2102 (2007).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  7. 7

    Metzen, E. et al. Mol. Biol. Cell 14, 3470–3481 (2003).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  8. 8

    Aragones, J. et al. Nature Genet. 40, 170–180 (2008).

    CAS  Article  PubMed  Google Scholar 

  9. 9

    Dezfulian, C., Raat, N., Shiva, S. & Gladwin, M. T. Cardiovasc. Res. 75, 327–338 (2007).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  10. 10

    Gonzalez, F. M. et al. Circulation 117, 2986–2994 (2008).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  11. 11

    Liu, X. et al. J. Am. Coll. Cardiol. 50, 808–817 (2007).

    Article  PubMed  Google Scholar 

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Mazzone, M., Carmeliet, P. A lifeline for suffocating tissues. Nature 453, 1194–1195 (2008).

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