Within a genome, genes are connected to each other through a complex network of interactions. One way to assess how robust and evolvable such genomic networks are is to introduce new links between unrelated genes.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Baba, T. et al. Mol. Syst. Biol. 10.1038/msb4100050 (2006).
Sopko, R. et al. Mol. Cell 21, 319–330 (2006).
Isalan, M. et al. Nature 452, 840–845 (2008).
Filipowicz, W., Bhattacharyya, S. N. & Sonenberg, N. Nature Rev. Genet. 9, 102–114 (2008).
Isaacs, F. J., Dwyer, D. J. & Collins, J. J. Nature Biotechnol. 24, 545–554 (2006).
Wall, M. E., Hlavacek, W. S. & Savageau, M. A. Nature Rev. Genet. 5, 34–42 (2004).
Hasty, J., Isaacs, F., Dolnik, M., McMillen, D. & Collins, J. J. Chaos 11, 207–220 (2001).
McDaniel, R. & Weiss, R. Curr. Opin. Biotechnol. 16, 476–483 (2005).
Elowitz, M. B. & Leibler, S. Nature 403, 335–338 (2000).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bennett, M., Hasty, J. Genome rewired. Nature 452, 824–825 (2008). https://doi.org/10.1038/452824a
Published:
Issue Date:
DOI: https://doi.org/10.1038/452824a
This article is cited by
-
Ins and Outs of Systems Biology vis-à-vis Molecular Biology: Continuation or Clear Cut?
Acta Biotheoretica (2010)
-
The Survival of the Fittest and the Reign of the Most Robust: In Biology and Elsewhere
Minds and Machines (2009)
