Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Systems biology

Genome rewired

Within a genome, genes are connected to each other through a complex network of interactions. One way to assess how robust and evolvable such genomic networks are is to introduce new links between unrelated genes.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: Intra-network communication.


  1. Baba, T. et al. Mol. Syst. Biol. 10.1038/msb4100050 (2006).

  2. Sopko, R. et al. Mol. Cell 21, 319–330 (2006).

    Article  CAS  ADS  Google Scholar 

  3. Isalan, M. et al. Nature 452, 840–845 (2008).

    Article  CAS  ADS  Google Scholar 

  4. Filipowicz, W., Bhattacharyya, S. N. & Sonenberg, N. Nature Rev. Genet. 9, 102–114 (2008).

    Article  CAS  Google Scholar 

  5. Isaacs, F. J., Dwyer, D. J. & Collins, J. J. Nature Biotechnol. 24, 545–554 (2006).

    Article  CAS  Google Scholar 

  6. Wall, M. E., Hlavacek, W. S. & Savageau, M. A. Nature Rev. Genet. 5, 34–42 (2004).

    Article  CAS  Google Scholar 

  7. Hasty, J., Isaacs, F., Dolnik, M., McMillen, D. & Collins, J. J. Chaos 11, 207–220 (2001).

    Article  CAS  ADS  Google Scholar 

  8. McDaniel, R. & Weiss, R. Curr. Opin. Biotechnol. 16, 476–483 (2005).

    Article  CAS  Google Scholar 

  9. Elowitz, M. B. & Leibler, S. Nature 403, 335–338 (2000).

    Article  CAS  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bennett, M., Hasty, J. Genome rewired. Nature 452, 824–825 (2008).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing