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A question of balance

When a disease-associated gene is mutated, is the cellular activity of its protein product enhanced or reduced? For at least one neurodegenerative disease, spinocerebellar ataxia 1, the answer seems to be both.

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Figure 1: Protein interactions implicated in spinocerebellar ataxia 1.


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Thompson, L. A question of balance. Nature 452, 707–708 (2008).

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