Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Neurodegeneration

A question of balance

Nature volume 452, pages 707–708 (2008)Cite this article

When a disease-associated gene is mutated, is the cellular activity of its protein product enhanced or reduced? For at least one neurodegenerative disease, spinocerebellar ataxia 1, the answer seems to be both.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Protein interactions implicated in spinocerebellar ataxia 1.

References

  1. Orr, H. T. & Zoghbi, H. Y. Annu. Rev. Neurosci. 30, 575–621 (2007).

    Article  CAS  Google Scholar 

  2. Katsuno, M. et al. Exp. Neurol. 200, 8–18 (2006).

    Article  CAS  Google Scholar 

  3. Li, S. & Li, X.-J. Mol. Neurodegen. 1, 19 (2006).

    Article  Google Scholar 

  4. Lim, J. et al. Nature 452, 713–718 (2008).

    Article  CAS  ADS  Google Scholar 

  5. Bates, G. P., Mangiarini, L. & Davies, S. W. Brain Pathol. 8, 699–714 (1998).

    Article  CAS  Google Scholar 

  6. Lam, Y. C. et al. Cell 127, 1335–1347 (2006).

    Article  CAS  Google Scholar 

  7. Shao, J. & Diamond, M. I. Human Mol. Genet. 16, R115–R123 (2007).

    Article  CAS  Google Scholar 

  8. Zuccato, C. et al. J. Neurosci. 27, 6972–6983 (2007).

    Article  CAS  Google Scholar 

  9. Kaltenbach, L. S. et al. PLoS Genet. 3, e82 (2007).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Leslie Michels Thompson is in the Departments of Psychiatry and Human Behavior, of Neurobiology and Behavior and of Biological Chemistry, University of California, Irvine, Gillespie 2121, Irvine, California 92696-4260, USA. lmthomps@uci.edu,

    Leslie Michels Thompson

Authors
  1. Leslie Michels Thompson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Thompson, L. A question of balance. Nature 452, 707–708 (2008). https://doi.org/10.1038/452707a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/452707a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing