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RNA interference

Generic block on angiogenesis

A virtue of using small interfering RNAs as therapeutics is their exquisite specificity. But when it comes to inhibiting blood-vessel growth, it seems that they can act generically without even entering a cell.

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Figure 1: Possible route of nonspecific siRNA action through Toll-like receptor 3.


  1. Nyberg, P., Xie, L. & Kalluri, R. Cancer Res. 65, 3967–3979 (2005).

    CAS  Article  Google Scholar 

  2. Folkman, J. Nature Rev. Drug Discov. 6, 273–286 (2007).

    CAS  Article  Google Scholar 

  3. Kleinman, M. E. et al. Nature 452, 591–597 (2008).

    ADS  Article  Google Scholar 

  4. Akira, S. Adv. Immunol. 78, 1–56 (2001).

    CAS  Article  Google Scholar 

  5. Medzhitov, R. & Janeway, C. Jr Immunol. Rev. 173, 89–97 (2000).

    CAS  Article  Google Scholar 

  6. Alexopoulou, L., Holt, A. C., Medzhitov, R. & Flavell, R. A. Nature 413, 732–738 (2001).

    ADS  CAS  Article  Google Scholar 

  7. Lin, Y., Liang, Z., Chen, Y. & Zeng, Y. J. Immunol. 176, 4147–4154 (2006).

    CAS  Article  Google Scholar 

  8. Lang, K. S. et al. J. Clin. Invest. 116, 2456–2463 (2006).

    CAS  Article  Google Scholar 

  9. Cameron, J. S. et al. J. Neurosci. 27, 13033–13041 (2007).

    CAS  Article  Google Scholar 

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Kalluri, R., Kanasaki, K. Generic block on angiogenesis. Nature 452, 543–545 (2008).

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