Three studies identify an association between genetic variation at a location on chromosome 15 and risk of lung cancer. But they disagree on whether the link is direct or mediated through nicotine dependence.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Somatic mutational profiles and germline polygenic risk scores in human cancer
Genome Medicine Open Access 11 February 2022
-
Gene-based partial least-squares approaches for detecting rare variant associations with complex traits
BMC Proceedings Open Access 29 November 2011
-
Breast cancer epidemiology according to recognized breast cancer risk factors in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial Cohort
BMC Cancer Open Access 17 March 2009
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hung, R. J. et al. Nature 452, 633–637 (2008).
Thorgeirsson, T. E. et al. Nature 452, 638–641 (2008).
Amos, C. I. et al. Nature Genet. doi:10.1038/ng.109 (2008).
Saccone, S. F. et al. Hum. Mol. Genet. 16, 36–49 (2007).
Berrettini, W. et al. Mol. Psych. 13, 368–373 (2008).
Chanock, S. J. et al. Nature 447, 655–660 (2007).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Chanock, S., Hunter, D. When the smoke clears .... Nature 452, 537–538 (2008). https://doi.org/10.1038/452537a
Published:
Issue Date:
DOI: https://doi.org/10.1038/452537a
This article is cited by
-
Somatic mutational profiles and germline polygenic risk scores in human cancer
Genome Medicine (2022)
-
Interactions between household air pollution and GWAS-identified lung cancer susceptibility markers in the Female Lung Cancer Consortium in Asia (FLCCA)
Human Genetics (2015)
-
Pleiotropy in complex traits: challenges and strategies
Nature Reviews Genetics (2013)
-
Causation and causal inference for genetic effects
Human Genetics (2012)
-
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia
Nature Genetics (2012)