Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Ion channels

Coughing up flu's proton channels

Two research teams have captured snapshots of the influenza virus's membrane-bound hydrogen-ion channel, which is essential for infection and virulence. Their findings agree on the basics, but differ in details.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: Depictions of the M2 proton channel.


  1. Stouffer, A. L. et al. Nature 451, 596–599 (2008).

    Article  ADS  CAS  Google Scholar 

  2. Schnell, J. R. & Chou, J. J. Nature 451, 591–595 (2008).

    Article  ADS  CAS  Google Scholar 

  3. Helenius, A. Cell 69, 577–578 (1992).

    Article  CAS  Google Scholar 

  4. Pinto, L. H. & Lamb, R. A. J. Biol. Chem. 281, 8997–9000 (2006).

    Article  CAS  Google Scholar 

  5. Sakaguchi, T., Tu, Q., Pinto, L. H. & Lamb, R. A. Proc. Natl Acad. Sci. USA 94, 5000–5016 (1997).

    Article  ADS  CAS  Google Scholar 

  6. Bright, R. A. et al. Lancet 366, 1175–1181 (2005).

    Article  CAS  Google Scholar 

  7. Wang, C., Takeuchi, K., Pinto, L. H. & Lamb, R. A. J. Virol. 67, 5585–5594 (1993).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Czabotar, P. E., Martin, S. R. & Hay, A. J. Virus Res. 99, 57–61 (2004).

    Article  CAS  Google Scholar 

  9. Salom, D., Hill, B. R., Lear, J. D. & DeGrado, W. F. Biochemistry 39, 14160–14170 (2000).

    Article  CAS  Google Scholar 

  10. Hu, J. et al. Proc. Natl Acad. Sci. USA 103, 6865–6870 (2006).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Miller, C. Coughing up flu's proton channels. Nature 451, 532–533 (2008).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing