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Diabetes

Missing links

Researchers have now probably pinpointed all the genes in the MHC genomic region that are risk factors in type 1 diabetes. As the MHC is unusually rich in genes involved in immunity, this is truly exciting.

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Figure 1: Type 1 diabetes and the contribution of HLA class I and class II proteins.

References

  1. Nejentsev, S. et al. Nature 450, 887–892 (2007).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  2. Atkinson, M. A. & Eisenbarth, G. S. Lancet 358, 221–229 (2001).

    Article  CAS  PubMed  Google Scholar 

  3. Aly, T. A. et al. Proc. Natl Acad. Sci. USA 103, 14074–14079 (2006).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Horton, R. et al. Nature Rev. Genet. 5, 889–899 (2004).

    Article  CAS  PubMed  Google Scholar 

  5. Zavattari, P. et al. Hum. Mol. Genet. 10, 881–889 (2001).

    Article  CAS  PubMed  Google Scholar 

  6. Nakanishi, K. et al. Diabetes 42, 1086–1093 (1993).

    Article  CAS  PubMed  Google Scholar 

  7. Roep, B. O., Arden, S. D., de Vries, R. R. & Hutton, J. C. Nature 345, 632–634 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Pinkse, G. G. et al. Proc. Natl Acad. Sci. USA 102, 18425–18430 (2005).

    Article  ADS  CAS  PubMed  Google Scholar 

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Roep, B. Missing links. Nature 450, 799–800 (2007). https://doi.org/10.1038/450799a

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