“Do not speak — unless it improves on silence” is generally wise advice, and is even vital for a subset of essential genes. New studies describe how, when appropriate, the silence of these genes is broken.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Jepsen, K. et al. Nature 450, 415–419 (2007).
Agger, K. et al. Nature 449, 731–734 (2007).
Lee, M. G. et al. Science 318, 447–450 (2007).
De Santa, F. et al. Cell 130, 1083–1094 (2007).
Lan, F. et al. Nature 449, 689–694 (2007).
Margueron, R., Trojer, P. & Reinberg, D. Curr. Opin. Genet. Dev. 15, 163–176 (2005).
Klose, R. J. & Zhang, Y. Nature Rev. Mol. Cell Biol. 8, 307–318 (2007).
Shi, Y. & Whetstine, J. R. Mol. Cell 25, 1–14 (2007).
Sparmann, A. & van Lohuizen, M. Nature Rev. Cancer 6, 846–856 (2006).
Lee, E. R., Murdoch, F. E. & Fritsch, M. K. Stem Cells 25, 2191–2199 (2007).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jones, R. Reversing the 'irreversible'. Nature 450, 357–359 (2007). https://doi.org/10.1038/450357a
Published:
Issue Date:
DOI: https://doi.org/10.1038/450357a
This article is cited by
-
The role of genetics in the establishment and maintenance of the epigenome
Cellular and Molecular Life Sciences (2013)
-
H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic geneBCL2determines ERα ligand dependency
The EMBO Journal (2011)
-
Epigenetic aberrations during oncogenesis
Cellular and Molecular Life Sciences (2011)
