Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Structural biology

A receptor unlocked

G-protein-coupled receptors govern many biological functions, yet little is known about the molecular basis of their activity. The structure of a prominent example of these receptors is now revealed.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Structure of a G-protein-coupled receptor.


  1. Pierce, K. L., Premont, R. T. & Lefkowitz, R. J. Nature Rev. Mol. Cell Biol. 3, 639–650 (2002).

    Article  CAS  Google Scholar 

  2. Kobilka, B. K. & Deupi, X. Trends Pharmacol. Sci. 28, 397–406 (2007).

    Article  CAS  Google Scholar 

  3. Palczewski, K. et al. Science 289, 739–745 (2000).

    Article  ADS  CAS  Google Scholar 

  4. Rasmussen, S. G. F. et al. Nature 450, 383–387 (2007).

    Article  ADS  CAS  Google Scholar 

  5. Cherezov, V. et al. Science doi:10.1126/science.1150577 (2007).

  6. Rosenbaum, D. M. et al. Science doi:10.1126/science.1150609 (2007).

  7. Day, P. W. et al. Nature Meth. doi:10.1038/nmeth1112 (2007).

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sprang, S. A receptor unlocked. Nature 450, 355–356 (2007).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing