Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Commentary
  • Published:

Benchmarks for ageing studies

Nature volume 450, pages 165–167 (2007)Cite this article

The hopes for improving human health during ageing are largely based on studies with animal models. But Linda Partridge and David Gems ask if we are learning the right lessons from ageing research.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Backcrossing model organisms.

References

  1. Kenyon, C. Cell 120, 449–460 (2005).

    Article  CAS  PubMed  Google Scholar 

  2. Piper, M. D. W., Selman, C., McElwee, J. J. & Partridge, L. Drug Discov. Today: Dis. Mod. 2, 249–256 (2005).

    CAS  Google Scholar 

  3. Smith, E. D., Kennedy, B. K. & Kaeberlein, M. Mech. Ageing Dev. 128, 106–111 (2007).

    Article  CAS  PubMed  Google Scholar 

  4. Toivonen, J. M. et al. PLoS Genet. 3, e95 (2007).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Bass, T. M., Weinkove, D., Houthoofd, K., Gems, D. & Partridge, L. Mech. Ageing Dev. 128, 546–552 (2007).

    Article  CAS  PubMed  Google Scholar 

  6. Gems, D. & Riddle, D. L. J. Gerontol. A 55, B215–B219 (2000).

    Article  CAS  Google Scholar 

  7. Sgrò, C. M. & Partridge, L. Am. Nat. 156, 341–353 (2000).

    Google Scholar 

  8. Miller, R. A., Harper, J. M., Dysko, R. C., Durkee, S. J. & Austad, S. N. Exp. Biol. Med. 227, 500–508 (2002).

    Article  CAS  Google Scholar 

  9. Miller, R. A. & Nadon, N. L. J. Gerontol. A 55, B117–B123 (2000).

    Article  CAS  Google Scholar 

  10. Kaeberlein, M., Kirkland, K. T., Fields, S. & Kennedy, B. K. PLoS Biol. 2, E296 (2004).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Orr, W. C. & Sohal, R. S. Exp. Gerontol. 38, 227–230 (2003).

    Article  CAS  PubMed  Google Scholar 

  12. Harper, J. M., Leathers, C. W. & Austad, S. N. Aging Cell 5, 441–449 (2006).

    Article  CAS  PubMed  Google Scholar 

  13. Garsin, D. A. et al. Science 300, 1921 (2003).

    Article  CAS  PubMed  Google Scholar 

  14. Christensen, K., Johnson, T. E. & Vaupel, J. W. Nature Rev. Genet. 7, 436–448 (2006).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We thank Brian Kennedy, Richard A. Miller and Scott D. Pletcher for helpful comments.

Author information

Authors and Affiliations

  1. Department of Biology, Linda Partridge and David Gems are at the Centre for Research on Ageing, University College London, The Darwin Building, Gower Street, London WC1E 6BT, UK.,

    Linda Partridge & David Gems

Authors
  1. Linda Partridge
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David Gems
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Partridge, L., Gems, D. Benchmarks for ageing studies. Nature 450, 165–167 (2007). https://doi.org/10.1038/450165a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/450165a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing