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Upregulation of erythropoietin receptor in human prostate carcinoma and high-grade prostatic intraepithelial neoplasia

Prostate Cancer and Prostatic Diseases volume 11, pages 143–147 (2008)Cite this article

Abstract

The aim of the present study was to investigate the differential expression of erythropoietin receptor (EPOR) in prostate carcinoma (PCa), high-grade prostatic intraepithelial neoplasia (PIN), prostatic hyperplasia (BPH) lesions and normal prostatic tissues by immunohistochemistry; and to test the hypothesis that upregulation of EPOR is a specific event for prostate carcinogenesis. An immunohistochemical analysis of EPOR was performed on 30 PCa, 50 BPH with/without inflammation lesions and 30 normal prostatic tissue samples. EPOR staining was quantitated and classified into normal expression and overexpression. Totally 16 high-grade PIN lesions were found in this study. Overexpression of EPOR was shown only in PCa and high-grade PIN. Statistical analysis demonstrated that higher median EPOR staining score of PCa and high-grade PIN in comparison with BPH (P<0.05) and higher median EPOR staining score of PCa compared with high-grade PIN (P<0.05). Our data demonstrate that upregulation of EPOR is not uncommon for PCa and upregulated EPOR in high-grade PIN suggests upregulation of EPOR is an early event for prostate carcinogenesis. The role of upregulated EPOR and possibly enhanced EPOR signaling in prostate carcinogenesis warrants further studying.

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Acknowledgements

This project was funded by a grant from Shanghai PuJiang Program 05PJ14005.

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  1. T Zhou and C Xu: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Urology, Changhai Hospital, The Second Military Medical University, Shanghai, PR China

    T Zhou, C Xu & Y Sun

  2. Department of Pathology, Changhai Hospital, The Second Military Medical University, Shanghai, PR China

    M He

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  1. T Zhou
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  2. C Xu
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Correspondence to Y Sun.

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Zhou, T., Xu, C., He, M. et al. Upregulation of erythropoietin receptor in human prostate carcinoma and high-grade prostatic intraepithelial neoplasia. Prostate Cancer Prostatic Dis 11, 143–147 (2008). https://doi.org/10.1038/sj.pcan.4500995

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