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Exercise can prevent and even reverse adverse effects of androgen suppression treatment in men with prostate cancer

Prostate Cancer and Prostatic Diseases volume 10, pages 340–346 (2007)Cite this article

Abstract

Side effects accompanying androgen deprivation therapy (ADT), including sarcopenia, loss of bone mass and reduction in muscle strength, can compromise physical function, particularly in older patients. Exercise, specifically resistance training, may be an effective and cost-efficient strategy to limit or even reverse some of these adverse effects during and following therapy. In this review, we discuss common morphological and physiological ADT-related side effects or ‘Androgen Deprivation and Sarcopenia-Related Disorders’ and the existing clinical trials incorporating physical exercise in prostate cancer patients receiving active therapy. Further, training concepts and guidelines are provided for prescribing resistance exercise programs for this population.

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Authors and Affiliations

  1. Vario Health Institute, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia

    D A Galvão & R U Newton

  2. School of Human Movement Studies, University of Queensland, Brisbane, Queensland, Australia

    D R Taaffe

  3. Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia

    N Spry

  4. Faculty of Medicine, University of Western Australia, Nedlands, Western Australia, Australia

    N Spry

Authors
  1. D A Galvão
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  2. D R Taaffe
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  3. N Spry
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  4. R U Newton
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Correspondence to D A Galvão.

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Galvão, D., Taaffe, D., Spry, N. et al. Exercise can prevent and even reverse adverse effects of androgen suppression treatment in men with prostate cancer. Prostate Cancer Prostatic Dis 10, 340–346 (2007). https://doi.org/10.1038/sj.pcan.4500975

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  • DOI: https://doi.org/10.1038/sj.pcan.4500975

Keywords

  • androgen antagonists
  • skeletal muscle
  • exercise

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