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Global analysis of differentially expressed genes in androgen-independent prostate cancer

Prostate Cancer and Prostatic Diseases volume 10, pages 167–174 (2007)Cite this article

Abstract

Progression to androgen independent (AI) is the main cause of death in prostate cancer, and the mechanism is still unclear. By reviewing the expression profiles of 26 prostate cancer samples in a holistic view, we found a group of genes differentially expressed in AI compared with androgen-dependent groups (P-value<0.01, t-test). Focusing on apoptosis, proliferation, hormone and angiogenesis, we found a group of genes such as thioredoxin domain containing 5 , tumor necrosis factor receptor superfamily, member 10a , ribosomal protein S19 and Janus kinase 2 upregulated in AI prostate cancer, could play important roles in the transition from AD to AI and could be biomarkers of prognosis.

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Acknowledgements

This research is supported by a project 30371422 from the National Natural Science Foundation of China.

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  1. Q Wei and M Li: These two authors contribute equally to this paper.

Authors and Affiliations

  1. State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, PR, China

    Q Wei, X Fu, R Tang, M Jiang & Y Li

  2. Department of Urology, First Hospital, Peking University, Beijing, China

    M Li & Y Na

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Correspondence to Y Li.

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Wei, Q., Li, M., Fu, X. et al. Global analysis of differentially expressed genes in androgen-independent prostate cancer. Prostate Cancer Prostatic Dis 10, 167–174 (2007). https://doi.org/10.1038/sj.pcan.4500933

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