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Prostatic carcinosarcoma 15 years after combined external beam radiation and brachytherapy for prostatic adenocarcinoma: a case report

Prostate Cancer and Prostatic Diseases volume 9, pages 195–197 (2006)Cite this article

Abstract

A 65-year-old man with a history of combined pelvic external beam radiation therapy (EBRT) and brachytherapy for prostatic adenocarcinoma 15 years prior underwent total pelvic exenteration for presumed rectal sarcoma with prostatic invasion. Pathology revealed carcinosarcoma of prostatic origin. This patient exhibited the longest reported interval between initial presentation with prostatic adenocarcinoma and development of carcinosarcoma. This case is also the first reported case of prostatic carcinosarcoma occurring after combined EBRT and brachytherapy. The increasing use of such combination high-dose radiation therapy may potentially lead to an increased incidence of secondary malignancies such as prostatic carcinosarcoma in the future.

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References

  1. Tannenbaum M . Sarcomas of the prostate gland. Urology 1975; 5: 810–814.

    Article  CAS  Google Scholar 

  2. Varghese SL, Grossfeld GD . The prostatic gland: malignancies other than adenocarcinomas. Radiol Clin North Am 2000; 38: 179–202.

    Article  CAS  Google Scholar 

  3. Haddad JR, Reyes EC . Carcinosarcoma of the prostate with metastasis of both elements: case report. J Urol 1970; 103: 80–83.

    Article  CAS  Google Scholar 

  4. Dundore PA, Cheville JC, Nascimento AG, Farrow GM, Bostwick DG . Carcinosarcoma of the prostate. Report of 21 cases. Cancer 1995; 76: 1035–1042.

    Article  CAS  Google Scholar 

  5. Subramanian VS, Coburn M, Miles BJ . Carcinosarcoma of the prostate with multiple metastases: case report and review of the literature. Urol Oncol 2005; 23: 181–183.

    Article  Google Scholar 

  6. Sexton WJ, Lance RE, Reyes AO, Pisters PW, Tu SM, Pisters LL . Adult prostate sarcoma: the M. D. Anderson Cancer Center Experience. J Urol 2001; 166: 521–525.

    Article  CAS  Google Scholar 

  7. Smith BH, Dehner LP . Sarcoma of the prostate gland. Am J Clin Pathol 1972; 58: 43–50.

    Article  CAS  Google Scholar 

  8. Koleski FC, Turk TM, Wojcik EM, Albala DM . Carcinosarcoma of the prostate. World J Urol 1999; 17: 316–318.

    Article  CAS  Google Scholar 

  9. Ahlering TE, Weintraub P, Skinner DG . Management of adult sarcomas of the bladder and prostate. J Urol 1988; 140: 1397–1399.

    Article  CAS  Google Scholar 

  10. Zlotecki RA . External-beam radiotherapy in the management of carcinoma of the prostate. Cancer Control 2001; 8: 503–510.

    Article  CAS  Google Scholar 

  11. Brenner DJ, Curtis RE, Hall EJ, Ron E . Second malignancies in prostate carcinoma patients after radiotherapy compared with surgery. Cancer 2000; 88: 398–406.

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Division of Urologic Surgery and Duke Prostate Center, Duke University Medical Center, Durham, NC, USA

    T Y Tseng, J W Moul & K E Maloney

  2. Department of Pathology, Duke University Medical Center, Durham, NC, USA

    D W Sevilla

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  1. T Y Tseng
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  2. D W Sevilla
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  3. J W Moul
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  4. K E Maloney
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Correspondence to K E Maloney.

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Tseng, T., Sevilla, D., Moul, J. et al. Prostatic carcinosarcoma 15 years after combined external beam radiation and brachytherapy for prostatic adenocarcinoma: a case report. Prostate Cancer Prostatic Dis 9, 195–197 (2006). https://doi.org/10.1038/sj.pcan.4500870

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  • DOI: https://doi.org/10.1038/sj.pcan.4500870

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