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Patient with disseminated intravascular coagulation as the first manifestation of adenocarcinoma of the prostate. Risks of prostatic biopsy

Abstract

Disseminated intravascular coagulation (DIC) can be a rare initial manifestation of adenocarcinoma of the prostate. We present a case in which DIC was the symptom leading to the suspicion of a prostatic tumour. The performance of a prostate biopsy in this situation exacerbated the initial coagulation disorder. This case highlights the risks of prostate biopsy in patients with a suspicion of advanced adenocarcinoma of the prostate. The difficulty of treating DIC in this clinical situation is also discussed.

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References

  1. Green KB, Silverstein RL . Hipercoagulability in cancer. Hematol Oncol Clin North Am 1996; 10: 499–530.

    Article  CAS  Google Scholar 

  2. Tagnon HJ, Whitmore WF, Shulman P . Fibrinolysis in metastatic cancer of the prostate. Cancer 1952; 5: 9–12.

    Article  CAS  Google Scholar 

  3. Spector JI, Zimbler H . Cancer of the prostate presenting as disseminated intravascular coaugulation. Can Med Assoc J 1987; 136: 570–573.

    CAS  Google Scholar 

  4. San Miguel JF, Sánchez-Guijo F . Cuestiones en Hematología, 2nd edn, Ediciones Harcourt: Madrid, 2002.

    Google Scholar 

  5. Djavan B, Waldert M, Zlotta A, Dobronski P, Seitz C, Renzi M et al. Safety and morbidity of first and repeat transrectal ultrasound guided prostate needle biopsies: results of a prospective European prostate cancer detection study. J Urol 2001; 166: 856.

    Article  CAS  Google Scholar 

  6. Al Otaibi MF, Al-Taweel W, Bin-Saleh S, Herba M, Aprikian AG . Disseminated intravascular coagulation following transrectal ultrasound guided prostate biopsy. J Urol 2004; 171: 346.

    Article  CAS  Google Scholar 

  7. Kampel LJ . Disseminated intravascular coagulation in metastatic hormone refractory prostate cancer. J Clin Oncol 2003; 21: 3170–3171.

    Article  Google Scholar 

  8. Bick RL . Coagulation abnormalities in malignancy: a review. Semin Thromb Hemost 1992; 18: 353.

    Article  CAS  Google Scholar 

  9. Beacopoulos T, Kranides A, Mandalaki-Yianit T, Louizou K, Panagiotopoulou E, Dimopoulos C . Syndrome de coagulation intra-vasculaire dissémine et cancer de la prostate. J D'Urologie 1980; 86: 467–470.

    Google Scholar 

  10. Levi M, Cate HT . Disseminated intravascular coagulation. N Engl J Med 1999; 29: 586–592.

    Article  Google Scholar 

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Correspondence to M Navarro.

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Navarro, M., Ruiz, I., Martín, G. et al. Patient with disseminated intravascular coagulation as the first manifestation of adenocarcinoma of the prostate. Risks of prostatic biopsy. Prostate Cancer Prostatic Dis 9, 190–191 (2006). https://doi.org/10.1038/sj.pcan.4500854

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  • DOI: https://doi.org/10.1038/sj.pcan.4500854

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