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TGFBR1*6A is not associated with prostate cancer in men of European ancestry

Abstract

The TGFBR1*6A (*6A) variant in exon 1 of the TGFBR1 gene has been postulated as a putative tumor susceptibility allele in several studies. We have performed a case–control study in 537 men with histologically verified prostate cancer and in 488 unrelated controls to investigate the association of *6A with prostate cancer. Our results revealed that the frequency of the *6A allele does not differ in men with prostate cancer compared to healthy controls, even in a subset of age-matched cases and controls. There is no compelling evidence for an association of the *6A variant with prostate cancer.

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Acknowledgements

This work was supported by an award from the Urological Research Foundation, St Louis.

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Correspondence to B K Suarez.

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Suarez, B., Pal, P., Jin, C. et al. TGFBR1*6A is not associated with prostate cancer in men of European ancestry. Prostate Cancer Prostatic Dis 8, 50–53 (2005). https://doi.org/10.1038/sj.pcan.4500765

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